Glycemic Response of Citrus Limon, Pomegranate and Their Combinations in Alloxan- Induced Diabetic Rats

Present study was performed to investigate the effect of Citrus limon and Pomegranate juices alone and their combinations on blood glucose and plasma insulin levels in alloxan induced diabetic rats as compared to diabetic control. Decrease in blood glucose level by Citrus limon was highly significant in dose dependant manner but there was highly significant increase in plasma insulin levels at moderate dose and significant increase at high dose. However Pomegranate showed highly significant decrease in blood glucose, in inverse dose dependant manner i.e. maximum effect was observed at low dose. Whereas there was highly significant increase in plasma insulin level at all three doses. Whereas combination dose group CPJ-1 (0.4+5ml/kg) showed highly significant response on blood glucose and plasma insulin, which was maximum effect obtained among all treated groups. These results suggest that Citrus limon and Pomegranate has phytochemical and other essential nutrients which have reduced blood glucose levels, that works synergistically in combination. So it may be concluded that the response of citrus limon and pomegranate on blood glucose may be due to presence of flavonoids in these juices and a synergistic effect is observed by their combination.